Atlanta Center for Medical Research

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According to the National Institute of Mental Health, depression (major depressive disorder or clinical depression) is a common but serious mood disorder which affects how you feel, think, and handle daily activities such as sleeping, eating, or working. Untreated depression symptoms can last for weeks, months, or years and can lead to significant impairment, other health-related issues, and in some cases, suicide.

If you have been experiencing the following symptoms nearly every day for at least two weeks, you may be suffering from depression:

  • Persistent sad, anxious, or empty mood
  • Feelings of hopelessness, or pessimism
  • Difficulty concentrating, remembering, or making decisions
  • Feelings of guilt, worthlessness, or helplessness
  • Loss of interest or pleasure in hobbies and activities
  • Decreased energy or fatigue
  • Moving or talking more slowly
  • Feeling restless or having trouble sitting still
  • Irritability
  • Difficulty sleeping, early-morning awakening, or oversleeping
  • Appetite and/or weight changes
  • Thoughts of death or suicide, or suicide attempts

Suicidality is a complex public health problem with far-reaching consequences for individuals and families, as well as significant impacts on society at large. Suicide rates have increased from 1999 through 2014 with greater increases since 2006, indicating that the impact of suicide is growing over time. Suicidal ideas and behavior is common across the spectrum of mental health disorders although it is strikingly associated with mood disorders, particularly MDD.

Major Depressive Disorder can be treated, usually with medications and/or psychotherapy. However, researchers are looking for ways to better understand, diagnose and treat depression with suicidality. They are also studying strategies to personalize care for depression, such as identifying characteristics that predict which treatments will be most effective.

If you are experiencing thoughts of hurting yourself or suicide, please call National Suicide Prevention Lifeline at 1-800-273-8255


The Atlanta Center for Medical Research was founded in 1982 by Dr. Robert A. Riesenberg and is now one of the largest and most respected medical research institutions in the country. ACMR’s 150,000-square-foot, state-of-the-art, open-source research facility is a game changer for the medical research world. ACMR’s practices set the standard for medical research, facilitating the availability of safe and effective medicine to people everywhere.

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